Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study
نویسندگان
چکیده
منابع مشابه
Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study
BACKGROUND Varenicline is an effective pharmacotherapy to aid smoking cessation. However, its use is limited by continuing concerns about possible associated risks of serious adverse cardiovascular and neuropsychiatric events. The aim of this study was to investigate whether use of varenicline is associated with such events. METHODS In this retrospective cohort study, we used data from patien...
متن کاملCardiovascular and neuropsychiatric risks of varenicline and bupropion in smokers with chronic obstructive pulmonary disease.
BACKGROUND Varenicline and bupropion are effective smoking cessation treatments, but there are concerns about their safety in smokers with COPD. OBJECTIVE To investigate whether varenicline and bupropion are associated with serious adverse cardiovascular and neuropsychiatric events in smokers with COPD. METHODS In a retrospective cohort study, we used data from 14 350 patients with COPD inc...
متن کاملVarenicline, smoking cessation, and neuropsychiatric adverse events.
OBJECTIVE In 2009, the U.S. Food and Drug Administration issued a black box warning for varenicline regarding neuropsychiatric events. The authors used data from randomized controlled trials and from a large Department of Defense (DOD) observational study to assess the efficacy and safety of varenicline. METHOD The authors reanalyzed data from the 17 placebo-controlled randomized controlled t...
متن کاملUse of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study
OBJECTIVE To investigate whether varenicline is associated with an increased risk of serious cardiovascular events compared with another drug used for smoking cessation, bupropion. DESIGN Nationwide historical cohort study. SETTING Denmark, 2007-10. PARTICIPANTS New users of varenicline (n = 17,926) and bupropion (n = 17,926). MAIN OUTCOME MEASURES Individual level data on dispensed dru...
متن کاملPeriodontal Treatment and the Risks of Cardiovascular Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study
Objective Periodontal disease may predispose individuals to cardiovascular disease (CVD). Diabetes mellitus, especially in patients with severe periodontitis, increases the risk of CVD mortality. However, the outcomes of periodontal therapy vary among the different treatment modalities. We aim to investigate whether periodontal treatment could influence the occurrence of CVD in patients with ty...
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ژورنال
عنوان ژورنال: The Lancet Respiratory Medicine
سال: 2015
ISSN: 2213-2600
DOI: 10.1016/s2213-2600(15)00320-3